Jay shendure cv. Recognizing local Clevelander Jay Shendure, MD, PhD.

Jay shendure cv English Wikipedia. He is a Professor in the Department of Genome Sciences at the University of Washington School of Medicine and an Affiliate Investigator in the Human Biology Division at the Fred Hutchinson Cancer Research Center. (with Kueh and Shendure Labs) The Shendure Lab is part of the Howard Hughes Medical Institute and the Department of Genome Sciences at the University of Washington (Seattle, WA). Sort by citations Sort by year Most of our work exploits next-generation DNA sequencing which is effectively emerging as a broadly enabling microscope for the measurement of biological phenomena. Education: Harvard University, PhD, 2005 Experience: Somite Therapeutics · Education: Harvard Medical School · Location: Seattle · 500+ connections on LinkedIn. Genome Sciences Professor Email: shendure@uw. Edit Recent News and Activity Section. Riza M Daza 1. Research Scholar. ) sciHi-C follows the traditional paradigm of fixation, digestion, and re-ligation shared by all Hi-C assays (Steps 1 – 4), but uses a biotinylated bridge adaptor to incorporate a first As an undergraduate, he learned the fundamentals of molecular biology in the Biochemistry department before transitioning to the lab of Dr. Below is a histogram showing the full distribution of Hash Enrichment Ratios; Jay Shendure is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA Jay Shendure is an American scientist and human geneticist at the University of Washington. Jay Shendure as its newest Scientific Co-Founder. Jay Shendure, Executive Director of the Seattle Hub for Synthetic Biology and a professor of genome sciences and Scientific Director of the Brotman Baty Institute at the University of Washington School of Medicine. A human cell atlas of fetal gene expression. from Harvard Medical School before coming to the University of Washington to train in functional genomics with Stan Fields and Jay Shendure. If you identify any major omissions or other inaccuracies in the publication list, please let us know. Funding: This work was supported by a grant from the National Cancer Institute (CA160080 to J. Seattle Times Explore. is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, and Scientific Jay Shendure is an American scientist and human geneticist at the University of Washington. Schematic of smMIP method. 8543 Jay Shendure. Combining strengths from both labs, I developed sci-L3, which enables high-coverage single-cell whole-genome sequencing with throughput of 1M cells and generalizability to other assays such as target-seq and DNA/RNA co-assay4 Jay Shendure, MD, PhD 2 • 2018 Richard and Carol Hertzberg Prize University of California, San Diego • 2018 Nancy Andrews Physician-Scientist Lectureship Duke University • 2017 British Society of Genetic Medicine Lectureship British Society of Genetic Medicine • 2014 Cell “40 under 40”, Cell 40th Anniversary Cell Press Submitted [8] D Cacchiarelli, X Qiu, S Srivatsan, M Ziller, E Overbey, J Grimsby, P Pokharel, K Livak, S Li, A Meissner, T Mikkelsen, J Rinn, C Trapnell \‘Aligning single-cell developmental and reprogram-ming trajectories identi es molecular determinants Dr. Hi, I am Zukai Liu 刘族凯. 1 reference. Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision. Kimberly A Aldinger 1. 30, Iss: 11, pp 1084-1094 Although there is considerable variety in the details of each implementation, MAVE experiments share a basic framework, with key steps represented in Figure 2: (1) construction of a variant library (i. edu About Prof. The mission of our lab is to develop and apply new technologies and methods Jay Shendure. Zukai Liu. One approach is to experimentally measure the functional consequences of VUS, but to date this approach has been post hoc and low throughput. gs. Paul D Kingsley 3. . jay shendure (he/HIM), faculty Nasa is a professor within the Herbold Computational Biology Program of the Public Health Sciences Division at Fred Hutch Cancer Center. 5 days of gestation, in a single experiment. 1038/nbt1486 Abstract DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data They have folks like Jay Shendure on faculty, who are leading the pack in functional genomics. His team used exome sequencing to identify the basis of Mendelian disorders and autism In the spring of 2012, he moved to the University of Washington (Seattle), when he joined Jay Shendure's lab in the development of methods for the functional scoring of variants , studying epigenetic signatures and nucleosome patterns in cell-free DNA, and developing methods to functionally assess regulatory variants using massively parallel Email: shendure@uw. We are trying our best to delineate the scientific world with nicely designed experiments and Chengxiang Qiu, Beth K. Shendure, an HHMI Investigator and world leader in single-cell and functional genomic assays, has pushed the envelope on the scale of Multiplex Single Cell Profiling of Chromatin Accessibility by Combinatorial Cellular Indexing Darren A. Here we use massively parallel assays to measure the effects of nearly 2000 missense substitutions in the RING Sam Regalado MD-PhD Student (GS) (joint w/ Trapnell Lab) 2016 - 2024 Dissertation: "Scalable methods for genomic analysis of in vitro models of mammalian embryogenesis " (defended January 18, 2024) Gianluca Amadei # 1 2 3 , Charlotte E Handford # 1 2 4 , Chengxiang Qiu 5 , Joachim De Jonghe 6 7 , Hannah Greenfeld 2 , Martin Tran 2 , Beth K Martin 5 , Dong-Yuan Chen 2 , Alejandro Aguilera-Castrejon 8 , Jacob H Hanna 8 , Michael B Elowitz 2 9 , Florian Hollfelder 6 , Jay Shendure 5 9 10 11 , David M Glover 2 , Magdalena Zernicka-Goetz 12 13 Postdoctoral Fellow, Jay Shendure Lab, University of Washington, Seattle, WA The logic of science is beautiful, although science itself can also be vague and elusive. edu people. Caltech-UW TMC Cai Long lcai@ caltech. The cis-regulatory dynamics of embryonic de-velopment at single-cell resolution. La investigación de Shendure se centra Jay Shendure Professor of Genome Sciences (he/him) phone: (206) 685-8543 fax: (206) 685-7301 Foege S-210 Box 355065 shendure [ a t ] uw. Andrea Ventura, MD, PhD [email protected] 646-888-3069 Lab Phone. 171: 2019: Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq. I'm not sure about CV specifically, but I'm of the thought that what matters in an -omics (and perhaps computational in general) PhD is the methods and thinking you learn, which are Their goal is to, “Capture the entire biography, instead of just the last page,” Jay Shendure, MD, PhD, and the Hub’s executive director, told Inside Precision Medicine. ). Ylenia Cendon Florez. Lab Jay Shendure, UW. View Jay Shendure’s profile on LinkedIn, a professional community of 1 The mission of our lab is to develop and apply new technologies and methods for genetics, genomics and molecular biology. JL McFaline-Figueroa, AJ Hill, X Qiu, D Jackson, J Shendure, C Trapnell. Nature genetics 51 (9), 1389-1398, 2019. Jay Shendure is a human geneticist, Professor in Genome Sciences at the University of Washington School of Medicine, and Shendure Lab MPRAflow Pipeline. [17]Qi Qiu*, Peng Hu*, Xiaojie Qiu‡, Kiya W Govek, Pablo G C´amara, Hao Wu†. Steemers3, Cole Trapnell1, and Jay Shendure1 1University of Washington, Department of Genome Sciences, Seattle, WA 2Oregon Health and Science Single-cell combinatorial indexed Hi-C integrates the in situ Hi-C protocol with combinatorial cellular indexing to generate signal-rich bulk Hi-C maps that can be decomposed into single cell Hi-C maps. Chengxiang (CX) Qiu is a computational biologist specializing in single-cell transcriptomics and developmental biology. We are testing a new system for linking publications to authors. Wei Chen*,#, Junhong Choi*, Xiaoyi Li, Jenny F. Technology Development in Genomics. 206-685-8543. Articles Cited by Public access. His 2005 doctoral thesis with George Church included one of the first “Today we release in @biorxivpreprint a pair of related methods, DNA Ticker Tape & ENGRAM, for multiplex, temporally ordered genomic recording of cell lineage histories, enhancer & signal transduction activities, respectively led by the brilliant @_Choi_Junhong & @wchenomics 1/25” Princeton Üniversitesi, Harvard Üniversitesi, Harvard Medical School. The Hub launched with $75 million in funding from the Allen Institute and the CZI. These are list 2021年10月14日，马萨诸塞大学的 薛文 教授课题组 （姜婷婷为第一作者） 和华盛顿大学西雅图分校 Jay Shendure 以背靠背的形式在 Nature Biotechnology 上分别发表了文章 Deletion and replacement of long genomic sequences using prime editing和Precise genomic deletions using paired prime editing ， 开发新一代基因组编辑器能够纠正目前 Originally from Hebei, China, Cao received his bachelor’s degree in Biology from Peking University. BBI's Scientific Director Dr. [17]Qi Qiu*, Peng Hu*, Xiaojie Qiu‡, Kiya W Govek, Pablo G For my postdoc, I trained with Sunney Xie and Jay Shendure on improving chemistry and throughput of single-cell assays. Research Interests. Jay Shendure says that, even now, For a 30-year-old, Sudarshan Pinglay has an impressive CV: Ph. Jay Shendure and Dr. Professor of Genome Sciences, University of Washington. Assays MPRA. Martin & Jay Shendure. Currently, a comprehensive understanding of the genetic events that cause prostate cancer initiation and progression has not been technologically possible. Award PI Jay Shendure, UW. Ronnie Blecher-Gonen 1. Lewis for support in developing the experimental protocols, and members of the Shendure and Eichler labs for helpful discussions. BS, Tsinghua Univeristy [email protected] Read More. , is an associate professor in the Department of Genome Sciences at the University of Washington in Seattle. edu Jay Shendure is an Investigator of the Howard Hughes Medical Institute (HHMI), Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Brotman-Baty Institute for Precision Medicine. There he worked on new methods for DNA sequencing by molecular inversion probes and, after graduating, on multiplex genome editing using CRISPR . human. 478: 2019: Synthetic recording and in situ readout of lineage information in single cells. , the stratification of variants by function Jay Shendure. Our ongoing work generally falls into six areas. I had a fabulous time in Seattle visiting the University of Washington and learning more about some very innovative research that combines precision medicine, genomics, and data science. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. imported from Wikimedia project. ' Photo courtesy Matt Hagen [Editor's note: This feature piece was published in the UW Medicine Huddle on April 3, 2023] Jay Shendure. Lab Website >> Is this lab accepting permanent students? No. Number of News Articles 11. Malte Spielmann 5. 华盛顿大学Jay Shendure博士领导的研究团队详细描绘了这一过程的细节。 他们对来自83个胚胎的1240万个细胞核进行分析，这些胚胎覆盖从胚胎后期（胚胎第8天）到出生（出生后第0天）的产前发育阶段。 Publications For an up to date publication list, visit our Google Scholar! All accompanying code can be found on Github or a link to the repository is provided in the paper. Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA. One of the greatest perks of being in the field of science is being able to recognize one’s colleagues as a result of scientific excellence and innovation. Chengxiang Qiu. Addgene is a nonprofit plasmid repository dedicated to improving life science research. Prof. GeekWire Summit 2018 Speaker Seattle, Washington, United States, North America Oct 1, 2018. His 2005 doctoral thesis with George Church included Hannah Pliner (Genome Sciences; joint with Jay Shendure), 2015-present Serena Liu (Genome Sciences), 2015-present Rotation students: Andria Ellis (Genome Sciences), Spring 2017 Gesine Cauer (Genome Sciences), Winter 2017 April Lo (Genome Sciences), Fall 2016 Eliah Overbey (Genome Sciences), Winter 2016 Jonathan Packer (Genome Sciences), Fall 2015 Abadie, Clark, Valanparambil, et al. CoMotion HQ: Condon Hall on the 7th floor, The Eventarium ; 1100 Northeast Campus Parkway iCal; In this talk, Dr. , allelic series) of the sequence of interest, (2) delivery of this variant library to an in vitro or in vivo system, (3) the functional assay (i. Department of Biochemistry, University of Cambridge, Cambridge, UK. 5 and 13. Junhong Choi. Jay Shendure. e. edu 21 b Shendure Jay 9 Trapnell Cole Nature 574 (7777), 187-192, 2019. At UW, he heads one of the world’s 392 high-probability publications. Jay Shendure, MD, PhD is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, and Scientific Director of the Seattle Hub for Synthetic Biology (Allen-CZI-UW) and the Brotman Baty Institute for Precision Medicine. Diğer İsimler. Individual-level capture of high-quality single cell transcriptomes, Related to Figure 1. Includes free contact info & photos & court records. Michelle Archer. , Ph. Cole Trapnell & Jay Shendure. Here we set out to establish single-cell RNA sequencing of the whole embryo as a scalable platform for the systematic phenotyping of mouse genetic Jay Shendure is a Professor in the Department of Genome Sciences at the University of Washington, and an Investigator of the Howard Hughes Medical Institute. Through his graduate study, he worked in Jay Shendure’s lab to develop novel high-throughput single cell genomic techniques. Learn more about research in the Jay Shendure Lab. Most of the work of Shendure and his team broadly exploits next-generation DNA sequencing as Jay Shendure Professor of Genome Sciences, University of Washington Verified email at uw. D. Remember when the cineplex concept debuted and a family could pile into the car for a trip to one big theater where everyone could see a different movie at the same time in the same place? In recent years, longtime NIH grantee A manuscript published by BBI researchers Junyue Cao, Cole Trapnell and Jay Shendure profiled ~2 million cells, derived from 61 embryos staged between 9. Follow their code on GitHub. current; alumni; research; papers. He is a professor in the Department of Genome Sciences at the University of Washington School of Medicine [1] and an Affiliate Investigator in the Human Biology Division at the Fred Hutchinson Cancer Research Center. She earned her Ph. Gunderson3, Frank J. edu/ Methods for Programmable Gene Synthesis and Biotechnologist and medical student Jay Shendure is revolutionizing genetics with a new way to sequence DNA. Shendure's research is focused on developing and applying new JayShendure,MD,PhD 2013–2015 RubiconGenomics(ScientificAdvisoryBoard) 2012 MerckResearchLaboratories(ScientificConsultant) 2010–2011 HaloGenomics(ScientificAdvisoryBoard) 在一项新的研究中，华盛顿大学遗传学者Jay Shendure和他的团队利用他们开发出的一种新的细胞内记录系统来编码文本，对它进行测试。 资讯 生物在线 As an undergraduate, he learned the fundamentals of molecular biology in the Biochemistry department before transitioning to the lab of Dr. edu Lior Pachter Bren Professor of Computational Biology, Caltech Verified email Jay Shendure Print. Cole Trapnell, Jay Shendure †, Eileen EM Furlong . Not to mention the computing infrastructure to support such work. The mission of our lab is to develop and apply new technologies and methods for genetics, genomics and molecular biology. Using CRISPR/Cas9, he engineered tools that can record biological events in cells, providing researchers a window into molecular events that occurred while the cells were going through development and Jay Shendure's lab at the University of Washington has 27 repositories available. As a postdoctoral researcher in Jay Shendure’s lab at the University of Washington, CX Dr. edu. shendure@u. His 2005 doctoral thesis with George Church included one of the first Cole Trapnell, Jay Shendure †, Eileen EM Furlong . Four faculty members at the University of Washington have been elected to the National Academy of Sciences for 2022: Elizabeth Buffalo, professor and chair of physiology and biophysics; Joseph Mougous, professor of microbiology; Dr. Joachim De Jonghe & Florian Hollfelder. Jay Shendure Location: University of Washington, Genome Sciences Website: http://krishna. 1038/nature25981. Shendure has developed a new biotechnology to For a 30-year-old, Sudarshan Pinglay has an impressive CV: Ph. Title. Howard Hughes Medical Institute, Seattle, WA, USA. Genomics is the study of all of a person’s genes (the genome), including interactions of those genes with each other and with the Jay Shendure 1, Erez Lieberman Aiden 2 • Institutions (2) University of Washington 1 , Harvard University 2 01 Nov 2012 - Nature Biotechnology (Nature Publishing Group) - Vol. Jay Shendure is a professor of genome sciences at the University of Washington. ' Photo courtesy Matt Hagen [Editor's note: This feature piece was published in the UW Medicine Huddle on April 3, 2023] people. S1. Technology and Applications Advisory Board. He graduated summa cum laude from Princeton University in 1996 with a degree in JayShendure,MD,PhD 2013–2015 IngenuitySystems(ScientificAdvisoryBoard) 2013–2015 RubiconGenomics(ScientificAdvisoryBoard) 2012 MerckResearchLaboratories(ScientificConsultant) Jay Shendure is interested in developing and applying new technologies and methods for genetics, genomics, and molecular biology. Their research focuses on understanding genotype-phenotype mapping, Discovery Series with Dr. edu; PMID: 18846087 DOI: 10. As such, even with millions of genomes and medical records in hand, and even where there is a specific hypothesis Jay Shendure Lab. Most of our work exploits next-generation DNA sequencing which is effectively emerging as a broadly enabling microscope for the measurement of biological phenomena. edu | Phone: 206. Description This pipeline processes sequencing data from Massively Parallel Reporter Assays (MPRA) to create count tables for candidate sequences tested in the experiment. Advisors: Jay Shendure, David Baker and Cole Trapnell Seattle, Washington 8VC Bio-IT Fellow March 2022 to June 2022 Research and diligence on emerging protein sequencing companies Remote and part time Mentor: David Yang and David Moskowitz COVID testing research scientist March 2020 to January 2021 Seattle Coronavirus Action Network (SCAN) Jay Shendure es un científico estadounidense y genetista humano de la Universidad de Washington. Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazai, Chengxiang Qiu, Jean-Benoit Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, Jay Shendure#. Most genetic variants that contribute to the risk or severity of common and rare diseases fall in regions of the human genome that control the expression ORCID record for Jay Shendure. Sort. In 2005, he used off-the-shelf parts to determine the order of all the DNA bases in a How to say Jay Shendure in English? Pronunciation of Jay Shendure with 1 audio pronunciation, 1 meaning and more for Jay Shendure. Department of Genome Science. (A), Barplot showing the number of individual cells that pass (Y = yes, N = no) a Hash Enrichment Ratio (count of most abundant hash relative to second-most abundant) threshold of 3. Jay Shendure: The 2020 Leaders in Health Care Gold Award Winner for Achievement in Medical Research" Feb-19: Allen Institute "2 million-cell experiment traces how a mammal grows, cell by single cell" Feb-19: GeekWire "University of Washington researchers create massive genetic map of organ development" Jay Shendure’s cool job using genome science to assess the risk of disease . Shendure will describe our ongoing efforts to develop and apply new technologies aimed at reconstructing the entirety of mouse As a graduate student in the lab of genomics professor Jay Shendure, Will developed tools to better understand development and gene regulation. Recent News and Activity. Cusanovich1, Riza Daza1, Andrew Adey2, Hannah Pliner1, Lena Christiansen3, Kevin L. He graduated summa cum laude from Princeton University in 1996 and completed a Fulbright scholarship at Pune, India, in 1997. Cited by. May 29, 2019 at 6:00 am Updated May 30, 2019 at 5:50 am . The exercise of gene finding is a finite exercise or at least subject to the law of diminishing returns. (A) Molecular inversion probes (MIPs) consisting of two 16–24 nt “targeting arms” (dark gray) joined by a constant 28-nt “backbone” sequence (light gray) and a 12-nt degenerate “molecular tag” (red) were designed for the coding exons (light-blue rectangle) of 33 cancer-related genes. Jay Shendure, a native of Solon, Ohio, is one of the innovators sustaining its momentum . Jay Shendure is an American scientist and human geneticist at the University of Washington. Contributors. Publications. View author publications. a. Junyue Cao 1. featured Karina Barbosa 1 , Anagha Deshpande 1 , Marlenne Perales 1 , Ping Xiang 2 , Rabi Murad 1 , Akula Bala Pramod 1 , Anna Minkina 3 , Neil Robertson 4 , Fiorella Schischlik 5 , Xue Lei 1 , Younguk Sun 1 , Adam Brown 6 , Diana Amend 6 , Irmela Jeremias 6 , John G Doench 7 , R Keith Humphries 2 , Eytan Ruppin 5 , Jay Shendure 3 , Prashant Mali 8 Jay Shendure Professor of Genome Sciences (he/him) phone: (206) 685-8543 fax: (206) 685-7301 Foege S-210 Box 355065 shendure [ a t ] uw. If this is your lab: Add a depositor badge to your website. Targeting arms were complementary to sequences BOSTON — Somite Therapeutics, a tech-bio company harnessing big data and AI to pioneer novel cell replacement therapies, is thrilled to announce the addition of Prof. Es catedrático del Departamento de Ciencias Genómicas de la Facultad de Medicina de la Universidad de Washington [1] e investigador afiliado de la División de Biología Humana del Centro de Investigación del Cáncer Fred Hutchinson. Ziqi Jiao, BA Jay Shendure Lab, University of Washington, Seattle, WA, 2014–2021. He is a professor in the Department of Genome Sciences at the University of Washington School of Medicine and an Affiliate Investigator in the Human Biology Division at the Fred Hutchinson Cancer Research Center. “I did not understand a word, but I Jay Shendure's 719 research works with 89,518 citations and 9,510 reads, including: Streptococcus pneumoniae nasal carriage patterns with and without common respiratory virus detections in 2021年10月14日，马萨诸塞大学的薛文教授课题组（姜婷婷为第一作者）和华盛顿大学西雅图分校Jay Shendure以背靠背的形式在Nature Biotechnology上分别发表了文章Deletion and replacement of long genomic sequences using prime editing和Precise genomic deletions using paired prime editing，开发新一代基因组编辑器能够纠正目前无法实现 Jay Shendure is a geneticist recognized for his development and application of genomic technologies to outstanding challenges in genetics, molecular biology and developmental biology. Friday, May 10, 2024 11:30am – 1:00pm 11:30 – 13:00. University of Washington | Genome Sciences - Developmental Biology, Stem Cells & Aging. Danilo Maddalo, PhD The Jay Shendure Lab has deposited materials at Addgene for distribution to the research community. Cao earned his PhD in Genome Sciences from University of Washington and graduated within less than four years in 2019. Starita is an Associate Professor in the Department of Genome Sciences at the University of Washington and the Co-director of Brotman Baty Advanced Technology Lab. shendure@uw. A manuscript published by BBI researchers Junyue Cao, Cole Trapnell and Jay Shendure profiled ~2 million cells, derived from 61 embryos staged between 9. “It was my first seminar as an undergrad and Jay spoke about exome sequencing,” Pinglay said. His 2005 PhD included one of the first successful To assess PALS' scalability from a single domain to a full-length cDNA, we next targeted the entire coding sequence of human p53. In contrast to Gal4, for which we explicitly specified each mutant codon, we targeted p53 codons for replacement by degenerate (“NNN”) triplets, reducing the microarray features required to the number of codons (393 for p53) and allowing access to About Jay Shendure. S. Jay Shendure is leading Seattle to the forefront of precision medicine to treat and prevent cancer and other serious medical conditions. Trent Lectureship in Cancer Research Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, Lead Scientific Directorof the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Brotman Baty Institute for Precision Medicine. Massively parallel Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Jay Shendure, MD, PhD 2 Honors, Awards, Named Lectures • 2022 Mendel Lecturer European Society of Human Genetics • 2019 Richard Lounsbery Award (for extraordinary scientific achievement in biology & medicine) National Academy of Sciences • 2019 Jeffrey M. E-mail: cxqiu@uw. Dr. 为了解决这个问题，2020年11月13日，来自华盛顿大学 Jay Shendure 实验室的 曹俊越 博士（第一作者）在 Science 上发表了文章 A human cell atlas of fetal gene expression ， 通过研发和优化高通量单细胞测序技术sci-RNA-seq3分析了来自121个人类胎儿器官样本的超过400万个单细胞的基 In recent years, longtime NIH grantee Dr. Visiting University of Washington. featured research articles; featured review articles; preprint papers; pre-2007; all publications (PubMed) press. Michael A Zager 2. Affiliation 1 Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA. David Baker, Jay Shendure, Cole Trapnell, Riza Daza, Bill Noble, Evan Eichler, and Debbie Nickerson have been named to the 2022 Highly Cited Researchers list from Clarivate. instance of. This enabled readout by single-cell RNA-sequencing, as the T7-generated Jay Shendure Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA Seattle Hub for Synthetic Biology, Seattle, Washington, USA Jay Shendure has participated in 1 event, GeekWire Summit 2018 on Oct 1, 2018. Fan Zhang 4. You can also search for this author in PubMed PI: Dr. J Shendure, H Ji. He then entered the Medical Scientist Training Program at Harvard Medical School and JayShendure,MD,PhD 2013–2015 RubiconGenomics(ScientificAdvisoryBoard) 2012 MerckResearchLaboratories(ScientificConsultant) 2010–2011 HaloGenomics(ScientificAdvisoryBoard) Jay Shendure is an American scientist and human geneticist at the University of Washington. Shendure: Of course the future of genetics includes sequencing millions or perhaps billions of whole genomes, but I’ll be disappointed if generating and sifting through that data is all our field is capable of. Four UW researchers elected to the National Academy of Sciences for 2022. Is this lab accepting rotation students? No. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. Jay Shendure * †, 1, 2 and Stanley Fields * ‡, 1, 2 (Shendure and Akey 2015), nearly all such individual variants are exceedingly rare. However, conventional approaches for phenotyping may fail to detect subtle defects throughout the developing mouse 2. Conflict of Interest: none declared. Schwartz and Alexandra P. edu Steven Salzberg Bloomberg Distinguished Professor, Johns Hopkins University Verified email at jhu. Diana R O'Day 1. Jay Shendure, professor of Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Brotman Baty Institute for Precision Medicine. He is a professor in the Department of Genome Sciences at the University of Washington School Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Jay Shendure MD, PhD. Francis Collins. Sort by citations Sort by year Sort by title. Jay Shendure has been focused on applying a similar idea to genome science. Jay Shendure University of Washington School of Medicine shendure@uw. Kenneth A Matreyek 1 , Lea M Starita 1 , Jason J Stephany 1 , Beth Martin 1 , Melissa A Chiasson 1 , Vanessa E Gray 1 , Martin Kircher 1 , Arineh Khechaduri 1 , Jennifer N Dines 2 , Ronald J Hause 1 , Smita Bhatia 3 , William E Evans 4 , Mary V Relling 4 , Wenjian Yang 4 , Jay Shendure 5 6 , Douglas M Fowler 7 8 9 With the rapid development of nextgeneration high-throughput sequencing technology (Shendure, 2008), RNA-seq has become a new and important means of gene expression and transcriptome analysis, and Jay Shendure is an Investigator of the Howard Hughes Medical Institute (HHMI), Professor of Genome Sciences at the University of Washington, Director of the Allen Discovery Center for Cell Lineage Tracing, and Scientific Director of the Brotman-Baty Institute for Precision Medicine. 8543 The primary mission of our lab is to develop and apply new technologies at the interface of genomics, molecular biology and developmental biology. “Symbolic recording of signalling and cis-regulatory element activity to DNA” Nature (2024) Jay Shendure Lab. Meanwhile, researchers from Jay Shendure's lab at the University of Washington used the piggyBac transposon to insert the recombination sites into the genome as part of a DNA "cassette," which also included identifying barcodes and a promoter for a T7 phage RNA polymerase. Google Scholar Selected Papers All Selected Papers title = {Cross-modality Matching and Prediction of Perturbation Responses with Labeled Gromov-Wasserstein Optimal Transport}, author = 华盛顿大学西雅图分校Jay Shendure团队也采取了类似的策略，不过其重点在于实现更高效、更长DNA片段的缺失突变，该方法被命名为PRIME-Del 。首先，作者提出PRIME-Del的设计（图4c），并在HEK293T细胞内验证。 "Dr. He will be giving the Mendel Lecture on Tuesday June 14 at 13. Shendure was born and raised in northeastern Ohio, just outside of Cleveland. Jay Shendure is a pioneer and leader in genomics who has developed new technologies that make DNA sequencing faster, cheaper, and more useful—work that is tr Interpreting variants of uncertain significance (VUS) is a central challenge in medical genetics. KL Frieda, JM Linton, S Hormoz, J Choi, KHK Chow, ZS Singer, Jay Shendure Professor of Genome Sciences (he/him) phone: (206) 685-8543 fax: (206) 685-7301 Foege S-210 Box 355065 shendure [ a t ] uw. washington. Jay Ashok Shendure Figure S1: Fig. His lab investigates the genetic basis of human disease and develops new technologies for genetics, genomics and molecular biology, largely using next-generation DNA sequencing. Jay Shendure lab in the Department of Genome Sciences. Our ongoing work Jay Shendure, MD, PhD is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, and Scientific Director of the Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, Lead Scientific Directorof the Allen Discovery Center for Cell Lineage Tracing, and Scientific The Shendure Lab is part of the Howard Hughes Medical Institute and the Department of Genome Sciences at the University of Washington (Seattle, WA). My research is developing innovative models and technologies to systematically understand and reconstitute the mammalian life cycle. Zoom out: Zoom in: Orient graph vertically Download Graph Jay Shendure Professor of Genome Sciences, University of Washington Verified email at uw. [2] Shendure's research is focused on developing and applying new BBI's Scientific Director Dr. Shendure received his PhD in Genetics from Harvard University in 2005 and his MD at Harvard Medical School in 2007. sex or gender To help us prepare for what we are about to study in our class, we are going to explore the work of Jay Shendure. You can also search for this author in PubMed Download CV PDF File Members. Shendure is a professor of genome sciences at the University of Washington and the scientific program director for the Brotman Baty Institute for Precision Medicine. Jay Ashok Shendure; Statements. Joining me on the visit was Senator Patty Murray of Washington. featured Mouse models are a critical tool for studying human diseases, particularly developmental disorders 1. Genomics. Mei Deng 1. Nature biotechnology 26 (10), 1135-1145, 2008. “I did not understand a word, but I May 6, 2022. 685. Authors. Nobuhiko Hamazaki at University of Washington. As a postdoctoral researcher in Jay Shendure’s lab at the University of Washington, CX See Free Details & Reputation Profile for Jay Shendure (50) in Seattle, WA. Jay Shendure: 'Our mantra in the lab is to look for bottlenecks and then try to address those bottlenecks using clever methods. University of Washington. Search for: Our Partners. They identified hundreds of cell types and 56 trajectories, and collectively define thousands of corresponding marker genes and dynamics of The authors thank Joseph B. I am a Postdoc with Dr. doi: 10. Posted on March 22nd, 2019 by Dr. He talked to Mary Rice about his life and work. Evan Eichler named one of Time's 100 Most Influential People of 2022. The Shendure Lab is part of the Howard Hughes Medical Institute and the Department of Genome Sciences at the University of Dr. in Cell and Molecular Biology from New York University, where he was given the university-wide Outstanding Dissertation Award. Hiatt, Jerrod J. It is a special pleasure for me today to introduce to you the 2012 American Society Jay Shendure 1 , Hanlee Ji. They identified hundreds of cell types and 56 trajectories, and collectively define thousands of corresponding marker genes and dynamics of Jay Shendure is a pioneer and leader in genomics who has developed new technologies that make DNA sequencing faster, cheaper, and more useful—work that is tr Jay Shendure has been elected to the National Academy of Sciences. Verified email at uw. Jay Shendure, M. His 2005 PhD included one of the first successful Recognizing local Clevelander Jay Shendure, MD, PhD. Hannah A Pliner 2. Google Scholar. Year; Next-generation DNA sequencing. Nature 555 (7697), 538-542 2018. Science is experiencing a genomics revolution, and our very own Dr. By . 30hrs. He is author of more than 35 peer-reviewed publications, and is co-owner of six patents (and patent applications) dealing with the manipulation of nucleic acids. 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